Variants in GH, IGF1, and LEP genes associated with body traits in Santa Inês sheep

ABSTRACT: Growth hormone (GH), insulin-like growth factor 1 (IGF1), and leptin (LEP) can be candidate genes for association studies because they play vital roles in the metabolism process. Thus, this study aimed to identify variants these associated with body traits Santa Ines sheep. The following were recorded: weight at 100 (BW100) 240 days (BW240), average daily gain (ADG), withers (WH) croup (CH) heights, length (BL), thoracic (TG) leg (LG) girths, (TW) (CW) widths, depth (BD), rib eye area (REA), fat thickness (FT), carcass finishing score (CFS). Single-locus analysis was performed 11 IGF1, 18 LEP, 16 GH. Moreover, two haplotypes IGF1 one haplotype LEP evaluated analysis. single-locus revealed 23 suggestive additive effects (p < 0.05), but no effect found Bonferroni threshold. Haplotype 19 effects, of which ten threshold 0.0074). In gene, replacements ADG 20.51(7.37), CH 4.09(1.21), WH 3.52(1.20), BL 3.94(1.19), TG 3.88(1.30), TW 1.13(0.36), LG 3.40(1.08); while gene replacement BW100 1.83(0.51), BD −2.51(0.56), CFS −0.24(0.06). Therefore, there are sheep, useful marker-assisted selection.